NML News

Ignaseclant Shows Promise in CMT

News & Media

News coverage featuring work from the laboratory of Dr. Arnold was featured in Show Me Mizzou: "Mizzou's bench-to-bedside efforts support a new drug for a neuromuscular disorder with no cure."

Provisional Patent Filed for Therapeutic Strategy

News & Media

A provisional patent was filed by the laboratories of Dr. Arnold and Dr. Castoro for translational strategies targeting age-related functional decline.

Burst Dynamics Enable Human Working Memory

Publications, Trainee Highlights

Research from the laboratory of Dr. Kundu, led by Vladimir Omelyusik, was published in NeuroImage: "Frontotemporal bursting supports human working memory".

AAV9 Micro-Dystrophin Shows Therapeutic Promise

Publications

Research from the laboratory of Dr. Arnold was published in Molecular Therapy Advances: “Preclinical evaluation of INS1201 AAV9-micro-dystrophin via CSF administration as a potential therapy for Duchenne muscular dystrophy”.

Thermosensory Deficits Across Neuropathy Models

Publications, Trainee Highlights

Research from the laboratory of Dr. Castoro, led by Dr. Vaibhav Oberoi and in collaboration with Dr. Arnold, Dr. Moss and Dr. Saxena, was published in the Journal of the Peripheral Nervous System: “Behavioral thermoceptive responses and morphologic correlates in mouse models of CMT1A, HNPP, and aging”

Antibody-siRNA Therapy Targets Myotonic Dystrophy

Publications

Research from the laboratory of Dr. Arnold was published in the New England Journal of Medicine: “An Antibody-Oligonucleotide Conjugate for Myotonic Dystrophy Type 1”.

Engineered GM1 Mitigates ALS Pathology

Publications, Trainee Highlights

Research from the laboratory of Dr. Saxena, with key contributions from Dr. Tristin Dellazizzo Toth and Silvano Bond, was published in Advanced Science: “Engineered GM1 Intersects Between Mitochondrial and Synaptic Pathways to Ameliorate ALS Pathology”.

Disrupted Myelin Architecture in CMT

Publications, Trainee Highlights

Research from the laboratory of Dr. Moss, with key contributions from Marvis Arowolo, was published in Glia: “Aberrant Molecular Myelin Architecture in Charcot–Marie–Tooth Disease Type 1A and Hereditary Neuropathy With Liability to Pressure Palsies”.
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Reduced Motor Cortex Excitability in ALS

Publications, Trainee Highlights

Research from the laboratory of Dr. Arnold, led by Dr. Joe Viteri, was published in Neurobiology of Disease: “Reduced cortico-muscular output is associated with intrinsic hypoexcitability and reduced persistent inward currents in motor cortex neurons of TDP-43Q331K ALS mice”

SfN Regional Chapter Established

Outreach

The Society for Neuroscience has approved the new regional chapter “Missouri Show-Me Neuroscience,” led by President Dr. Moss, expanding opportunities for collaboration and community building across the region.

NML Representation at SfN Meeting

Scientific Conferences, Trainee Highlights

NML and Mizzou neuroscience had a strong showing at the 2025 Society for Neuroscience meeting, with trainees from the Arnold, Kundu, Moss and Saxena labs presenting posters across diverse research areas.

Trainees Showcase Research at HSRD

Scientific Conferences, Trainee Highlights

NML trainees presented research findings at the University of Missouri Health Sciences Research Day, an annual symposium highlighting innovation across the health sciences.