RNA Regulation in Neuromuscular Disease
The Nutter Lab investigates how RNA processing, transport and localization regulate neural and epithelial function in health and disease, with a focus on neurological and neuromuscular disorders including myotonic dystrophy and Charcot-Marie-Tooth disease. Using molecular, transcriptomic, organoid and mouse model approaches, the lab studies how RNA dysregulation disrupts tissue homeostasis, barrier function and biofluid composition across epithelial and nervous system tissues.
Lab Focus
Research Interests:
1. RNA splicing, transport, and localization in epithelial and neural tissues
2. Regulation of cerebrospinal fluid and aqueous humour homeostasis
3. RNA-mediated mechanisms in neuromuscular and inherited neurological disease
4. Cross-tissue principles of RNA dysregulation in genetic disorders
Areas of Expertise:
1. RNA biology and transcriptome analysis
2. Epithelial cell biology and biofluid-producing tissues
3. Mouse models of neurological and neuromuscular disease
4. Integrative approaches linking molecular mechanisms to physiology